Ivo M B Francischetti Selected Research

Proteins (Proteins, Gene)

1/2017	An insight into the sialome of Hyalomma excavatum.
1/2016	Molecular Diversity between Salivary Proteins from New World and Old World Sand Flies with Emphasis on Bichromomyia olmeca, the Sand Fly Vector of Leishmania mexicana in Mesoamerica.
8/2015	(99m)Tc-ixolaris targets glioblastoma-associated tissue factor: in vitro and pre-clinical applications.
1/2015	Salivary Thromboxane A2-Binding Proteins from Triatomine Vectors of Chagas Disease Inhibit Platelet-Mediated Neutrophil Extracellular Traps (NETs) Formation and Arterial Thrombosis.
9/2012	Inhibition of tissue factor by ixolaris reduces primary tumor growth and experimental metastasis in a murine model of melanoma.
1/2012	Simukunin from the salivary glands of the black fly Simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses.
8/2011	Alboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity.
6/2009	The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity.
5/2004	Penthalaris, a novel recombinant five-Kunitz tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick vector of Lyme disease, Ixodes scapularis.
2/2003	Inhibition of hemostasis by a high affinity biogenic amine-binding protein from the saliva of a blood-feeding insect.

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Ivo M B Francischetti Research Topics

Disease

19	Inflammation (Inflammations) 09/2021 - 02/2003
13	Thrombosis (Thrombus) 01/2023 - 01/2010
7	Malaria 01/2020 - 08/2002
7	Lyme Disease (Disease, Lyme) 01/2014 - 09/2002
4	Hemorrhage 01/2021 - 07/2006
4	Infections 08/2017 - 02/2008
3	Neoplasms (Cancer) 09/2021 - 09/2012
3	Cerebral Malaria 01/2020 - 06/2008
3	Chagas Disease (American Trypanosomiasis) 05/2015 - 01/2012
3	Edema (Dropsy) 09/2014 - 01/2011
2	COVID-19 05/2023 - 09/2021
2	Thromboembolism 12/2013 - 06/2013
2	Autoimmune Diseases (Autoimmune Disease) 06/2012 - 06/2009
2	Coma (Comas) 03/2012 - 06/2008
1	Atypical Hemolytic Uremic Syndrome 01/2023
1	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2023
1	Thromboinflammation 09/2021
1	Ischemic Stroke 01/2021
1	Parasitemia 01/2020
1	HIV Infections (HIV Infection) 08/2017
1	Babesiosis (Piroplasmosis) 01/2016
1	Leishmaniasis 01/2016
1	Glioblastoma (Glioblastoma Multiforme) 08/2015
1	Pulmonary Embolism 01/2015
1	Leukemia 01/2014
1	Rabies (Hydrophobia) 04/2013
1	Neoplasm Metastasis (Metastasis) 09/2012
1	Melanoma (Melanoma, Malignant) 09/2012
1	Yellow Fever 08/2011

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 01/2017 - 08/2002
9	AnticoagulantsIBA 08/2017 - 05/2002
6	Thromboplastin (Tissue Factor)IBA 09/2021 - 02/2008
5	Salivary Proteins and PeptidesIBA 01/2021 - 01/2011
4	CollagenIBA 01/2015 - 01/2010
3	EnzymesIBA 09/2021 - 01/2014
3	VaccinesIBA 01/2016 - 09/2002
3	Epinephrine (Adrenaline)FDA LinkGeneric 01/2015 - 06/2013
2	Blood Coagulation Factors (Coagulation Factor)IBA 09/2021 - 02/2008
2	Pancreatic Elastase (Elastase)IBA 01/2021 - 01/2012
2	Carrier Proteins (Binding Protein)IBA 01/2015 - 11/2010
2	ProteomeIBA 04/2013 - 08/2010
2	Peptides (Polypeptides)IBA 01/2012 - 08/2010
2	Cathepsin GIBA 01/2012 - 01/2011
2	Heparin (Liquaemin)FDA LinkGeneric 08/2011 - 02/2008
2	A-factor (Streptomyces)IBA 08/2011 - 12/2010
2	Rose BengalIBA 12/2010 - 01/2010
2	LipocalinsIBA 01/2008 - 02/2003
1	NeuroserpinIBA 05/2023
1	Plasminogen Activators (Plasminogen Activator)IBA 05/2023
1	Plasminogen Activator Inhibitor 1IBA 05/2023
1	Complement System Proteins (Complement)IBA 01/2023
1	Thrombin FDA Link 01/2023
1	DNA (Deoxyribonucleic Acid)IBA 09/2021
1	Histones (Histone)IBA 09/2021
1	ThrombomodulinIBA 09/2021
1	Deoxyribonucleases (DNase)FDA Link 01/2020
1	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2020
1	Cell-Free Nucleic AcidsIBA 01/2020
1	PlasminogenIBA 01/2018
1	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2018
1	Toll-Like Receptors (Toll-Like Receptor)IBA 08/2017
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	RadiopharmaceuticalsIBA 08/2015
1	ThromboxanesIBA 01/2015
1	CarrageenanIBA 09/2014
1	Peroxidase (Myeloperoxidase)IBA 09/2014
1	tempolIBA 01/2014
1	LectinsIBA 01/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2014
1	AntioxidantsIBA 01/2014
1	Polysaccharides (Glycans)IBA 01/2014
1	TrypsinIBA 01/2014
1	Superoxide DismutaseIBA 01/2014
1	Factor XIa (Coagulation Factor XIa)IBA 12/2013
1	PolyphosphatesIBA 12/2013
1	Factor XII (Hageman Factor)IBA 06/2013
1	Factor Xa InhibitorsIBA 09/2012
1	PAR-2 ReceptorIBA 09/2012
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2012
1	AllergensIBA 06/2012
1	defibrotideIBA 03/2012
1	Nucleotide AptamersIBA 03/2012
1	Therapeutic UsesIBA 03/2012
1	Glycoproteins (Glycoprotein)IBA 01/2012
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2012
1	Factor Xa (Coagulation Factor Xa)IBA 08/2011
1	phosphatidylethanolamineIBA 08/2011
1	Phospholipids (Phosphatides)FDA LinkGeneric 08/2011
1	Phosphatidylcholines (Phosphatidylcholine)IBA 08/2011
1	ferric chlorideIBA 08/2011
1	Chymases (Chymase)IBA 01/2011
1	EicosanoidsIBA 12/2010
1	nitrophorin (nitrophorin 1)IBA 12/2010
1	Thromboxane A2 (A2, Thromboxane)IBA 11/2010
1	cysteinyl-leukotrieneIBA 11/2010
1	von Willebrand FactorIBA 01/2010

Therapy/Procedure

3	Lasers (Laser) 06/2013 - 01/2010
1	Therapeutics 08/2017
1	Intravenous Injections 01/2015